Without 16-goal striker David Connolly the Dons may have been pleased to settle for a point before kick-off but they thoroughly deserved their victory.
Damien Francis scored the first goal in the 31st minute when he slid the ball past the exposed Marcus Hahnemann. It silenced the large Reading following and was a sign of things to come.
Readings attacks were too often ended by the offside flag while Andy Hughes afternoon ended in spectacular fashion.
He careered off the park behind the Wimbledon goal and put a leg straight through a McDonalds advertising hoarding.
However, the Dons almost doubled their lead when Mark Williams' looping header was cleared off the line.
Reading, from being almost two goals down, almost snatched an immediate equaliser.
Steve Sidwell, who had already brought a good diving save from Kelvin Davis, was put clear as Nicky Forster stabbed a pass to him just five yards out. Somehow the ball got entangled in his feet and the defence recovered to scramble the ball clear.
Reading floundered in the second half with ineffectual build-ups as Wimbledon controlled the game.
Neil Shipperley almost scored Wimbledons second goal in the 71st minute. He drove a free kick against the Royals wall and drove the rebound beyond the keeper but it smashed off the post and to safety.
Forster almost snatched an equaliser when he fired a shot past Davis only to see it flash just wide.
Wimbledon finally scored a deserved second goal in the 85th minute. Patrick Agyemang and Jermaine Darlington set up Alex Tapp who rocketed a shot into the net to secure a comprehensive victory.