The Dons winger was substituted ten minutes before half time in the away defeat at Oldham on Tuesday night having sustained a thigh injury.
Therefore, Chadwick is now a serious doubt for the game at The Withdean Stadium on Saturday afternoon.
"It's looking as though Luke is going to struggle to make this weekend, we're still trying to fully assess the extent of the injury but he's certainly a doubt," Dons' first team coach Alex Rae told the club's official website.