A solitary Paul Edwards strike after just eight minutes was enough to give the Seasiders the edge against a Dons side which enjoyed the bulk of the possession.
The visitors, who were just a point behind their hosts before kick-off made a bright start but were hit by a quick break when Blackpool keeper Bradley Jones parried a shot by Nicholas Rizzo.
The ball was fed quickly to Keigan Parker whose cross found Edwards on the edge of the area.
The former Wrexham winger, making his first appearance after a six-week spell on the side lines with a leg injury, lifted the ball over the young Dons keeper David Martin to give his side a lead they did not deserve on the balance of play.
The visitors, with a distinct high advantage, continued to press and Izale McLeod missed a couple of chances from close range.
Blackpool boss Colin Hendry revealed after the game that defenders Mark McGregor and Peter Clarke had only been declared fit for play after a late fitness test, while striker John Murray had to be replaced at half time by young Serbian striker Zarko Grabovac.
The youngster, signed from Dutch Football just two weeks ago, missed a golden chance to put Blackpool further ahead half midway through the second half but his shot on the turn went straight at Martin.
At the other end the Dons continued to threaten particularly from set pieces with Ben Chorley, Cameroon international Michel Pensee-Bilong and Clive Platt all going close.
In on occasionally bad tempered game referee Mr Evans showed half a dozen yellow cards, but despite being full of passion, the Dons could not back into the game.